This an extremely sophisticated analysis of one of the most troubling aspects of chemotherapy, namely the tendency over time for a patient to develop resistance to the agent being applied. The Goldie-Coldman model for resistance is one of the best known in chemotherapy. Since it operates at a level of some mathematical complexity, some physicians and biochemists have found it somewhat off-putting. However, in this book, the authors have carefully minimized mathematical complexity and emphasized an intuitive approach which is very approachable by most oncologists. This book is an excellent resource, one which should be in the library of every chemotherapist,