mathematics

This book is considered a classic in its field, and, indeed, had few serious competitors up until about eight years ago. But, with new undergraduate texts that appeared since then, the weaknesses of Stryer's text became more apparent.

1. The text is not structured well enough: its 37 chapters are divided into a number of titled topics, but it is apparent that students would find it easier to manage if each chapter were divided into 4-8 major topics,just the way it has been done in 'Student companion for Stryer's Biochemistry' by Gumport et al.

2. It seems that the book owes part of its popularity to the fact that the most difficult topics have either been left out or are covered very briefly and with serious lack of rigor. The most notorious example is incredibly poor coverage of biochemical energetics. Since most readers are life science majors or medical students with little background in thermodynamics and electrochemistry, this ought be treated in a more detailed and more serious manner. Many students find the treatment of energetic aspects of oxidative phosphorylation and photosynthesis so unclear tham majority of them find it necessargy to consult some other text to figure things out. The same goes for enzyme kinetics - it is just inexcusable for a text of this size to completely ignore discussion of bisubstrate kinetics and other common complex kinetic systems.

As a conclusion, Stryer's Biochemistry 4th ed. is still readable and up-to date text. However, nowadays there are several other texts of about the same size and aiming at the same audience, but with much less things to complain about. As a TA in an undergraduate biochemistry course, I found texts by Mathews and van Holde (1996), Garrett and Grisham (1995) and Lehninger, Nelson and Cox (1993) to be more adequate for the needs of most students. My students especially praise Matthews and van Holde as a book which enables them to easily grasp even the most difficult concepts.

A disorganized muddle of clinical correlations, chemical mechanisms, and pathways, the text attempts to destroy an otherwise beautiful topic. It is difficult to extract the main pts and organize the information into a coherent fashion. But fortunately there are other texts, and a map showing how all the pathways converge and a table w/enzymes organized by mechanism w/cofactor, rxn info will be golden. With books like Lippincott's Reviews and Voet&Voet, youll be biochemistry's biggest fan in no time.

As with any intro text, this book tries to reach the largest audience possible. The problem is that it has deficiencies in many areas. The initial sections on DNA are short, completely avoiding any detailed mechanisms about DNA replication or transcription, putting those with a background that is stronger in chemistry at a disadvantage. When it comes to proteins, the book seems to have no trouble giving detailed mechanisms but the mechanisms are often obscure and poorly labeled (notably in serine proteases and metal-ion catalysis) making the information more difficult for those stronger in regular biology. Perhaps the worst part is that this book, which was chosen for my professor based on its integrated web courseware, has a website that is often unresponsive and seems to only work on old versions of Netscape. Nonetheless, I still keep a copy on my bookshelf for reference since the sections on proteins (notwithstanding the diagrams) are actually pretty good. All in all, an okay text and decent reference but certainly not for someone looking to pursue a career in biochemistry, molecular biology, or medicine. If you have a choice, the new Lehninger 4th edition is way better.